NMR-based assignment of isoleucine vs. allo-isoleucine stereochemistry?
Organic & Biomolecular Chemistry Pub Date: 2017-11-01 DOI: 10.1039/C7OB01995E
Abstract
A simple 1H and 13C NMR spectrometric analysis is demonstrated that permits differentiation of isoleucine and allo-isoleucine residues by inspection of the chemical shift and coupling constants of the signals associated with the proton and carbon at the α-stereocentre. This is applied to the estimation of epimerisation during metal-free N-arylation and peptide coupling reactions.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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