l-Proline catalyzed multicomponent one-pot synthesis of gem-diheteroarylmethane derivatives using facile grinding operation under solvent-free conditions at room temperature
RSC Advances Pub Date: 2014-01-06 DOI: 10.1039/C3RA44568B
Abstract
An efficient and straightforward L-proline catalyzed one-pot synthesis of a series of biologically relevant gem-(β-dicarbonyl)arylmethanes has been developed via a three-component reaction between indoles, aldehydes and C–H activated acids by grinding them together under solvent-free conditions at room temperature. Mild reaction conditions, high atom-economy, good yields, and eco-friendliness are some of the salient features of the present protocol.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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