New monodentate chiral phosphite ligands for asymmetric hydrogenation

Chemical Communications Pub Date: 2003-07-22 DOI: 10.1039/B306793A

Abstract

We report the synthesis of new chiral monodentate phosphite ligands with a biphenyl backbone, the axial chirality of which is introduced early in the synthesis and locked by a chiral alkylenedioxy bridge. We also describe results obtained with these ligands in rhodium-catalysed asymmetric hydrogenation of various substrates.

Graphical abstract: New monodentate chiral phosphite ligands for asymmetric hydrogenation
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