Mechanoenzymatic peptide and amide bond formation?

Green Chemistry Pub Date: 2017-05-02 DOI: 10.1039/C7GC00615B

Abstract

Mechanochemical chemoenzymatic peptide and amide bond formation catalysed by papain was studied by ball milling. Despite the high-energy mixing experienced inside the ball mill, the biocatalyst proved stable and highly efficient to catalyse the formation of α,α- and α,β-dipeptides. This strategy was further extended to the enzymatic acylation of amines by milling, and to the mechanosynthesis of a derivative of the valuable dipeptide L-alanyl-L-glutamine.

Graphical abstract: Mechanoenzymatic peptide and amide bond formation
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