Mechanochemical organic synthesis
Chemical Society Reviews Pub Date: 2013-05-09 DOI: 10.1039/C3CS35526H
Abstract
Recently, mechanical milling using a mixer mill or planetary mill has been fruitfully utilized in organic synthesis under solvent-free conditions. This review article provides a comprehensive overview of various solvent-free mechanochemical organic reactions, including metal-mediated or -catalyzed reactions, condensation reactions, nucleophilic additions, cascade reactions, Diels–Alder reactions, oxidations, reductions, halogenation/aminohalogenation, etc. The ball milling technique has also been applied to the synthesis of calixarenes, rotaxanes and cage compounds, asymmetric synthesis as well as the transformation of biologically active compounds.
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Journal Name：Chemical Society Reviews
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CAS no.: 89640-58-4
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