Pd/P/dba-Promoted cascade annulations to produce fused medium-sized sulfoximine polyheterocycles?
Organic Chemistry Frontiers Pub Date: 2019-08-29 DOI: 10.1039/C9QO00880B
Abstract
The Pd-catalyzed multicomponent reactions of NH-sulfoximine, aryl iodide and norbornadiene (NBD) are reported to chemoselectively produce fused medium-sized sulfoximine polyheterocycles in good to excellent yields. The addition of the dibenzylideneacetone (dba) ligand was found to be useful for this tandem annulation reaction. Under the optimized conditions, a broad range of 3D-type heterocyclic sulfoximines with good functional group tolerance were generated.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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