A one-pot multicomponent approach to a new series of morphine derivatives and their biological evaluation?
Organic & Biomolecular Chemistry Pub Date: 2017-08-29 DOI: 10.1039/C7OB01924F
Abstract
A novel and facile domino reaction has been developed to synthesize a variety of new derivatives from hydromorphone, amines and paraformaldehyde in good yields in a catalyst-free fashion with high atom efficiency. The products show a mixed MOR/DOR biological characteristic which makes them valuable for further study as opioid analgesics.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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