A simple method for the determination of enantiomeric composition of propranolol enantiomers

Analyst Pub Date: 2012-10-31 DOI: 10.1039/C2AN36003A

Abstract

A simple method of room temperature phosphorescence is proposed for the determination of propranolol enantiomeric composition based on β-cyclodextrin as the chiral host and bromocyclohexane as the heavy atom. Enantiomeric complexes are formed upon binding of the propranolol enantiomer to β-cyclodextrin, and the sign of the resultant phosphorescence signals allows for the identity of the propranolol enantiomers configuration to be determined successfully.

Graphical abstract: A simple method for the determination of enantiomeric composition of propranolol enantiomers
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