Palladium-catalyzed direct asymmetric C–H bond functionalization enabled by the directing group strategy
Chemical Science Pub Date: 2020-07-09 DOI: 10.1039/D0SC03052J
Abstract
In the past decade, selective C–C and C-heteroatom bond construction through palladium-catalyzed direct C–H bond functionalization has been extensively studied by employing a variety of directing groups. Within this category, direct asymmetric C(sp2)–H and C(sp3)–H activation for the construction of highly enantiomerically enriched skeletons still progressed at a slow pace. This minireview briefly introduces the major advances in the field for palladium-catalyzed direct asymmetric C–H bond functionalization via the directing group strategy.
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Journal Name:Chemical Science
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CAS no.: 89640-58-4