Novel synthetic baicalein derivatives caused apoptosis and activated AMP-activated protein kinase in human tumor cells?
Organic & Biomolecular Chemistry Pub Date: 2011-08-24 DOI: 10.1039/C1OB06094E
Abstract
Studies on the anti-proliferative activities of novel baicalein derivatives demonstrated that compounds 8 and 9 were able to activate AMPK by enhancing the levels of phosphorylated AMPKα, and showed more potent anti-proliferative effects than baicalein and AICAR in A431, SK-OV-3, DU 145 and HeLa cells, suggesting an alternative therapeutic approach for benzyl baicalein in cancer therapy.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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