Overproduction and identification of butyrolactones SCB1–8 in the antibiotic production superhost Streptomyces M1152?
Organic & Biomolecular Chemistry Pub Date: 2016-05-10 DOI: 10.1039/C6OB00840B
Abstract
Gamma-butyrolactones (GBLs) are signalling molecules that control antibiotic production in Streptomyces bacteria. The genetically engineered strain S. coelicolor M1152 was found to overproduce GBLs SCB1–3 as well as five novel GBLs named SCB4–8. Incorporation experiments using isotopically-labelled precursors confirmed the chemical structures of SCB1–3 and established those of SCB4–8.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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