Ionic liquid phase synthesis (IoLiPS) of 2-aminothiazoles and imidazo[1,2-a]pyridines?
RSC Advances Pub Date: 2014-09-18 DOI: 10.1039/C4RA08009B
Abstract
An efficient and practical ionic liquid phase synthesis (IoLiPS) of aza-heterocycles has been developed through a ‘catch-and-release’ strategy using an ionic liquid-supported hypervalent iodine reagent. The hypervalent iodine played a dual role as a reagent and as a soluble support. This strategy provided a combinatorial approach for the synthesis of 2-aminothiazoles and imidazo[1,2-a]pyridines directly from substituted acetophenones in good to excellent yields. The use of an ionic liquid supported reagent offered better isolation of the products by simple extraction with organic solvents.
![Graphical abstract: Ionic liquid phase synthesis (IoLiPS) of 2-aminothiazoles and imidazo[1,2-a]pyridines](http://scimg.chem960.com/usr/1/C4RA08009B.jpg)
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Journal Name：RSC Advances
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