Nickel-catalyzed amination of aryl fluorides with primary amines?
Chemical Communications Pub Date: 2017-12-12 DOI: 10.1039/C7CC08181B
Abstract
The Ni-catalyzed cross-coupling reaction between aryl fluorides and primary amines was enabled by the 1,2-bis(dicyclohexylphosphino)benzene (DCYPBz) or 1,2-bis(dicyclohexylphosphino)ethane (DCYPE) ligands. Both N-alkyl- and N-aryl-substituted primary amines participated in the selective reaction to form secondary amines. This protocol would potentially be useful for late-stage diversification of fluorinated compounds with complex structures for the synthesis of functionally interesting aniline derivatives.
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Journal Name：Chemical Communications
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