One-pot synthesis of trisubstituted ureas from α-chloroaldoxime O-methanesulfonates and secondary amines?

RSC Advances Pub Date: 2015-06-30 DOI: 10.1039/C5RA10060G

Abstract

Trisubstituted ureas can be synthesized in a one-pot fashion from bench-stable α-chloroaldoxime O-methanesulfonates and secondary amines under mild reaction conditions. Two practical protocols have been developed to achieve various urea syntheses from both secondary aromatic amines and aliphatic amines.

Graphical abstract: One-pot synthesis of trisubstituted ureas from α-chloroaldoxime O-methanesulfonates and secondary amines
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