One-pot synthesis of GABA amides via the nucleophilic addition of amines to 3,3-disubstituted cyclopropenes?
Organic & Biomolecular Chemistry Pub Date: 2015-07-30 DOI: 10.1039/C5OB01462J
Abstract
A one-pot synthesis of various GABA amides has been demostrated, employing the nucleophilic addition of primary and secondary amines across the double bond of cyclopropene-3-carboxamides, followed by ring-opening of the resulting donor–acceptor cyclopropanes and subsequent in situ reduction of enamine (imine) intermediates.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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