Microwave-assisted preparation of 4-amino-3-cyano-5-methoxycarbonyl-N-arylpyrazoles as building blocks for the diversity-oriented synthesis of pyrazole-based polycyclic scaffolds?
Organic & Biomolecular Chemistry Pub Date: 2014-11-04 DOI: 10.1039/C4OB01951B
Abstract
The synthesis of 4-amino-3-cyano-N-arylpyrazoles A based on a Thorpe–Ziegler cyclization as the key step has been achieved using microwave activation. Via a new diversity-oriented synthetic pathway, these highly functionalized building blocks allowed the access to various heteroaromatic scaffolds such as pyrazolo-pyridines B, pyrazolo-pyrimidines C and pyrazolo-oxadiazoles D. Interestingly, these platforms contain three to four reactive sites that could be used for post-functionalization in order to further increase the molecular diversity.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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