One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature?

Organic & Biomolecular Chemistry Pub Date: 2012-08-02 DOI: 10.1039/C2OB25889G

Abstract

An efficient general synthetic approach has been developed to synthesize pyrazole-containing bisphosphonate (N-BPs) esters from chromenone derivatives via a sequential two-step reaction in one pot at ambient temperature in good to excellent yields. This protocol provides a new convenient method to prepare lipophilic bisphosphonate precursors with potential activities.

Graphical abstract: One-pot syntheses of novel pyrazole-containing bisphosphonate esters at room temperature
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