A novel pathway for the thermolysis of N-nitrosoanthranilates using flash vacuum pyrolysis leading to 7-aminophthalides?
Organic & Biomolecular Chemistry Pub Date: 2020-10-13 DOI: 10.1039/D0OB01946A
Abstract
Flash vacuum pyrolysis of methyl N-methyl-N-nitrosoanthranilate leads to elimination of nitric oxide and disproportionation of the formed N-radical to 7-(methylamino)phthalide and methyl N-methylanthranilate. This transformation was found to be a convenient, solvent-free method for the preparation of 7-(methylamino)phthalides. An alternative route through pyrolysis of N-benzyl-N-methyl anthranilates was also investigated.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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