A protecting group-free divergent synthesis of natural benzofurans via one-pot synthesis of 2-bromo-6-hydroxybenzofurans?
Organic & Biomolecular Chemistry Pub Date: 2019-01-24 DOI: 10.1039/C8OB03102A
Abstract
2-Bromo-6-hydroxybenzofurans are potentially versatile intermediates for the divergent synthesis of numerous benzofuran-based natural products and their analogues. Herein we report the first one-pot strategy for the efficient synthesis of 2-bromo-6-hydroxybenzofurans. The present protocol provides shorter routes for the synthesis of moracins M, N, O and P; gramniphenols F and G; and morunigrol C using a protecting group-free approach.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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