Metal-free oxidative acylation/cyclization of N-methacryloyl-2-phenylbenzoimidazole with aryl aldehydes: an easy access to benzimidazo[2,1-a]isoquinolin-6(5H)-ones?
Organic & Biomolecular Chemistry Pub Date: 2019-10-24 DOI: 10.1039/C9OB01979K
Abstract
A metal-free radical cyclization strategy has been developed for the synthesis of fused benzimidazo[2,1-a]isoquinolin-6(5H)-one derivatives from N-methacryloyl-2-arylbenzoimidazole and aryl aldehydes using 70% tert-butylhydroperoxide in water (TBHP). The reaction proceeds through a sequential acyl radical addition/cyclization strategy. This method is useful for the generation of biologically relevant tetracyclic scaffolds in a single-step process.
![Graphical abstract: Metal-free oxidative acylation/cyclization of N-methacryloyl-2-phenylbenzoimidazole with aryl aldehydes: an easy access to benzimidazo[2,1-a]isoquinolin-6(5H)-ones](http://scimg.chem960.com/usr/1/C9OB01979K.jpg)
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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