3-Methylene-2,4-chromandione in situ trapping: introducing molecular diversity on 4-hydroxycoumarin?

RSC Advances Pub Date: 2015-11-26 DOI: 10.1039/C5RA22440C

Abstract

3-Methylene-2,4-chromandione trapped in a solid-state stable Mannich adduct, is released in solution. In the presence of different nucleophiles, this highly reactive intermediate allows the introduction of molecular diversity on C-3 position of 4-hydroxycoumarin.

Graphical abstract: 3-Methylene-2,4-chromandione in situ trapping: introducing molecular diversity on 4-hydroxycoumarin
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