Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues?

Chemical Communications Pub Date: 2015-08-12 DOI: 10.1039/C5CC05571G

Abstract

We report the production, isolation, and characterization of jadomycins with seven-, nine-, and ten-membered E-rings, all of which are unique natural product ring scaffolds. This significantly expands the scope of a non-enzymatic biosynthetic step in jadomycin biosynthesis in order to produce novel natural products.

Graphical abstract: Jadomycins, put a bigger ring in it: isolation of seven- to ten-membered ring analogues
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