A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines?

Chemical Communications Pub Date: 2012-01-25 DOI: 10.1039/C2CC18001D

Abstract

A novel and efficient route for the preparation of quinazolin-4(3H)-imines via a palladium-catalyzed three-component reaction of carbodiimide, isocyanide, and nucleophile is described. The palladium-catalyzed isocyanide insertion is believed to be the key step during the reaction process.

Graphical abstract: A palladium-catalyzed three-component reaction for the preparation of quinazolin-4(3H)-imines
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