Multi-functional fluorescent probe for Hg2+, Cu2+ and ClO? based on a pyrimidin-4-yl phenothiazine derivative?

Analyst Pub Date: 2013-07-22 DOI: 10.1039/C3AN01214J

Abstract

A multi-functional fluorescent probe based on PzDPM (10-ethyl-3,7-di(pyrimidin-4-yl)-10H-phenothiazine) for Hg2+, Cu2+ and ClO? has been synthesized and characterized. The probe comprises an electron-donating fluorophore core of 10-ethylphenothiazine and two Hg2+-specific chelating arms of pyrimidin-4-yl. The 10-ethylphenothiazine also acts as a Cu2+/ClO?-specific reactive moiety. PzDPM exhibits green fluorescence and selectively senses Hg2+/Cu2+ upon coordination/reaction in acetonitrile (MeCN), and behaves as a turn-off chemosensor or ratiometric chemodosimeter, respectively. On the other hand, PzDPM is very weakly emissive in aqueous solution but acts as an excellent turn-on chemodosimeter for ClO? in 1?:?4 (v/v) MeCN?:?Tris–HCl (10 mM, pH = 7.0) with a maximum fluorescent intensity increase of over 110-fold. The probe PzDPM allows the determination of Hg2+, Cu2+ and ClO? at 10?7 M levels with satisfactory selectivity.

Graphical abstract: Multi-functional fluorescent probe for Hg2+, Cu2+ and ClO? based on a pyrimidin-4-yl phenothiazine derivative
Recommended Literature