Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines?
Chemical Communications Pub Date: 2015-12-22 DOI: 10.1039/C5CC08724D
Abstract
Metalated arylmethylisonitriles readily add to 2-chloropyridines to afford imidazo[1,5-a]pyridines. Analogous additions to imidoyl chlorides and a chloroquinoline provide imidazoles and an imidazo[1,5-a]quinolone which, like imidazo[1,5-a]pyridines, are valuable heterocycles for pharmaceutical synthesis.
![Graphical abstract: Isonitrile alkylations: a rapid route to imidazo[1,5-a]pyridines](http://scimg.chem960.com/usr/1/C5CC08724D.jpg)
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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