Iodine-promoted stereoselective amidosulfenylation of electron-deficient alkynes?

RSC Advances Pub Date: 2018-06-27 DOI: 10.1039/C8RA04374D

Abstract

Iodine-promoted three-component synthesis of substituted β-amino sulfides has been developed starting from a propargyl ester, aliphatic secondary amine, and disulfide. This protocol provides a step-economic and highly regioselective entry to trisubstituted olefins with good substrate scope and functional group tolerance.

Graphical abstract: Iodine-promoted stereoselective amidosulfenylation of electron-deficient alkynes
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