Natural product analogues: towards a blueprint for analogue-focused synthesis
Chemical Society Reviews Pub Date: 2017-07-04 DOI: 10.1039/C6CS00842A
Abstract
For the first time a general overview of approaches to the synthesis of natural product analogues is presented. This reflects a process of evolution of natural product synthesis which has accelerated in the years since the implementation of diversity-oriented synthesis, which has emerged in parallel with collective synthesis, diverted total synthesis and the preparation of truncated natural products optimised for biological activity. A method involving computational assessment for the validation of core-modified natural product analogues is discussed.
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Journal Name：Chemical Society Reviews
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CAS no.: 89640-58-4
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