Nanotechnology lights up the antitumor potency by combining chemotherapy with siRNA
Journal of Materials Chemistry B Pub Date: 2021-07-22 DOI: 10.1039/D1TB01379C
Abstract
Nanotechnology-based combination anticancer therapy offers novel approaches to overcome the limitations of single-agent administration. The emerging siRNA technology combined with chemotherapy has shown considerable promise in anticancer therapy. There are three main challenges in the fabrication of siRNA/chemotherapeutic drug co-loaded nanovectors: adequate cargo protection, precise targeted delivery, and site-specific cargo release. This review presents a summary of the nanosystems that have recently been developed for co-delivering siRNA and chemotherapeutic drugs. Their combined therapeutic effects are also discussed.
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Journal Name：Journal of Materials Chemistry B
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CAS no.: 89640-58-4
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