Iodine-mediated regio- and stereoselective iodothiocyanation of alkynes in aqueous ethanol?
Organic & Biomolecular Chemistry Pub Date: 2018-09-27 DOI: 10.1039/C8OB02216J
Abstract
Iodothiocyanation of alkynes with ammonium thiocyanate (NH4SCN) and molecular iodine (I2) has been demonstrated in aqueous ethanol, which enables efficient synthesis of a series of functional β-iodo vinylthiocyanates in good to excellent yields under mild reaction conditions without the need for any protection.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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