Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical?

Chemical Communications Pub Date: 2011-03-25 DOI: 10.1039/C0CC05764A

Abstract

Amyloid nitroxyl radical (nitroxide) ligands were used to detect amyloid-β fibrils, the main constituents of senile plaques in Alzheimer's disease, using anisotropic ESR spectra, and were found to affect the aggregation process due to the radical functionality. These compounds have great potential as novel and multifunctional probes, combining spin labels, spin probes, and fluorescence probes.

Graphical abstract: Monitoring the aggregation processes of amyloid-β using a spin-labeled, fluorescent nitroxyl radical
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