MIDA boronate allylation – synthesis of ibuprofen?
RSC Advances Pub Date: 2020-08-18 DOI: 10.1039/D0RA03338C
Abstract
MIDA boronates are among the most useful reagents for the Suzuki–Miyaura reaction. This chemistry typically generates new bonds between two aromatic rings, thereby restricting access to important areas of chemical space. Here we demonstrate the coupling of MIDA boronates to allylic electrophiles, including a new synthesis of the well-known COX inhibitor ibuprofen.
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Journal Name：RSC Advances
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CAS no.: 89640-58-4
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