Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination?

CHEMICAL COMMUNICATIONSCHEM COMMUN Pub Date: 2016-01-25 DOI: 10.1039/C6CC00501B

Abstract

We report on a straightforward strategy to fabricate bioactive glycosylated gold nanoparticles via a combination of RAFT polymerization, carbohydrate ligation through reductive amination and thiol–gold self-assembly. This approach is used for the design of gold nanoparticles decorated with the complex sialylated glycan Neu5Ac-α-2-6-Gal, and we demonstrate multivalent and specific recognition between the nanoparticles, lectins and hemagglutinin on the surface of the influenza virus.

Graphical abstract: Influenza-binding sialylated polymer coated gold nanoparticles prepared via RAFT polymerization and reductive amination
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