Iodine-mediated construction of polyfunctionalized arylazopyrazoles from β-ketoesters or 2-arylpyrazol-3-ones and arylhydrazines?
Organic & Biomolecular Chemistry Pub Date: 2016-06-29 DOI: 10.1039/C6OB01158F
Abstract
This paper describes step-economic iodine-mediated construction of functionalized arylazopyrazoles in the presence of catalytic AgNO3 starting from simple β-ketoesters and two equivalents of arylhydrazines. This cascade reaction includes in situ α-iodination of β-ketoesters, pyrazol-3-one formation, substitution with a nitrogen nucleophile, and oxidation/aromatization.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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