A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions?
Organic Chemistry Frontiers Pub Date: 2018-01-09 DOI: 10.1039/C7QO00751E
Abstract
4-(2-Substituted-[1,3]thiazolo[3,2-a]benzimidazol-3-yl)quinazolin-2-amines were prepared by the multi-component reaction of 2,4-dichloroquinazoline, terminal alkynes, secondary amines, and 1H-benzo[d]imidazole-2(3H)-thione in the presence of a palladium窶田opper catalyst. This one-pot process provided an efficient and successful approach for the synthesis of a new thiazolo[3,2-a]benzimidazole linked-quinazoline scaffold with good to high yields.
![Graphical abstract: A one-pot synthetic approach for the construction of a thiazolo[3,2-a]benzimidazole-linked quinazoline scaffold via palladium-catalyzed reactions](http://scimg.chem960.com/usr/1/C7QO00751E.jpg)
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Journal Name：Organic Chemistry Frontiers
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