A photoredox- or metal-catalyzed three-component cyanoalkylsulfonylation reaction of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite, and cycloketone oxime esters: synthesis of cyanoalkylsulfonylated benzoxepines?
Organic Chemistry Frontiers Pub Date: 2021-09-03 DOI: 10.1039/D1QO01183A
Abstract
A visible light photocatalyzed or metal-catalyzed three-component cyanoalkylsulfonylation of 1-(allyloxy)-2-(1-arylvinyl)benzenes, potassium metabisulfite and cyclobutanone oxime esters is developed. This reaction provides a direct approach to diverse cyanoalkylsulfonylated benzoxepines in moderate to good yields. This transformation displays a wide substrate scope, wide functional group tolerance and the potential for product derivatization.
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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