Highly enantioselective hydrogenation of 2-substituted-2-alkenols catalysed by a ChenPhos–Rh complex?
Chemical Communications Pub Date: 2013-11-13 DOI: 10.1039/C3CC47727D
Abstract
Highly enantioselective hydrogenation of a variety of 2-substituted-2-alkenols has been achieved using a ChenPhos–Rh complex as catalyst, giving ≥99% ee for most substrates. Optically active antifungal agent amorolfine was first synthesised using hydrogenation as the key step.
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Journal Name：Chemical Communications
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