Improving the carboxyamidomethyl ester for subtilisin A-catalysed peptide synthesis?

Organic & Biomolecular Chemistry Pub Date: 2012-07-03 DOI: 10.1039/C2OB25662B

Abstract

A series of novel glycine esters was evaluated for efficiency in subtilisin A-CLEA-catalysed peptide synthesis. The reactivity of the easily accessible carboxyamidomethyl (Cam) ester was further enhanced by elongating it with an amino acid residue, thereby creating more recognition space for subtilisin A.

Graphical abstract: Improving the carboxyamidomethyl ester for subtilisin A-catalysed peptide synthesis
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