HFIP promoted thio(hetero)arylation of imidazoheterocycles under metal- and base-free conditions?
Chemical Communications Pub Date: 2021-07-22 DOI: 10.1039/D1CC03089B
Abstract
A new reaction methodology has been developed for HFIP promoted Thio(hetero)arylation of imidazoheterocycles under metal and base-free conditions. To the best of our knowledge, this is the first report that describes linking of imidazopyridines with electron deficient heteroarenes through a sulphur atom and also for the synthesis of most of these compounds. The reaction conditions are well tolerated by almost all kinds of 2-chloroheteroarenes and a wide range of imidazoheterocycles. The synthesized compounds can show significant biological properties.
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Journal Name：Chemical Communications
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CAS no.: 89640-58-4
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