Lewis acid promoted fluorine-alkoxy group exchange reactions for the synthesis of 5-alkoxy-4,4-difluoroisoxazoline systems?
Organic & Biomolecular Chemistry Pub Date: 2019-02-21 DOI: 10.1039/C9OB00097F
Abstract
Fluorine-alkoxy group exchange reactions of fluorinated isoxazoline derivatives promoted by Lewis acids to give various 5-alkoxylated 4,4-difluoroisoxazolines via SN1 type processes in good to excellent yields are reported. Sterically demanding phenol substrates such as 2,6-diphenylphenol gave novel aryl substituted products via electrophilic aromatic substitution.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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