Ionic liquid-assisted transdermal delivery of sparingly soluble drugs?

Chemical Communications Pub Date: 2010-01-14 DOI: 10.1039/B907462G

Abstract

We report the first successful application of a novel IL-assisted non-aqueous microemulsion stabilized by a blend of two nontoxic surfactants, polyoxyethylene sorbitan monooleate (Tween-80), and sorbitan laurate (Span-20) for transdermal delivery of acyclovir, which is insoluble or sparingly soluble in water and most common organic liquids.

Graphical abstract: Ionic liquid-assisted transdermal delivery of sparingly soluble drugs
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