Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent??

CrystEngComm Pub Date: 2015-06-02 DOI: 10.1039/C5CE00753D

Abstract

Micronization, polymorphism, and cocrystal formation are well-known strategies to modify the characteristics of pharmaceutical ingredients. In this work, recrystallization induced by compressed CO2 as an antisolvent was investigated as a new way to produce aminosalicylate (ASA) polymorphs and cocrystals. Three ASA isomers were first recrystallized as single species. Isomerism has a particular influence on the product characteristics. The 5-ASA isomer was produced as micrometric spherical crystals with improved flow properties but no change in the crystal lattice was observed. 3-ASA recrystallized as micrometric spheres in a less dense crystal packing than that of the raw compound, and the 4-ASA isomer did not exhibit noticeable changes in the morphology or crystal lattice. Cocrystallization of each isomer with nicotinamide resulted in the production of an ASA:NCTA cocrystal only in the case of 4-ASA.

Graphical abstract: Influence of isomerism on recrystallization and cocrystallization induced by CO2 as an antisolvent
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