Highly regio- and stereoselective intermolecular tandem reaction to synthesize chloro-substituted 1,3-butadienes?

Chemical Communications Pub Date: 2010-01-14 DOI: 10.1039/B923464K

Abstract

A palladium catalyzed highly regio- and stereoselective intermolecular tandem reaction of alkynes, CuCl2 and alkenes by a sequence of chloropalladation/Heck reaction to produce chloro-substituted 1,3-dienes is achieved.

Graphical abstract: Highly regio- and stereoselective intermolecular tandem reaction to synthesize chloro-substituted 1,3-butadienes
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