F-THENA: a chiral derivatizing agent for the determination of the absolute configuration of secondary aromatic alcohols with a self-validating system?
Organic & Biomolecular Chemistry Pub Date: 2016-11-01 DOI: 10.1039/C6OB02255C
Abstract
F-THENA is designed as an alternative fluorine-containing chiral derivatizing agent (CDA). The fluorine atom functions exclusively as a reporter which can directly sense an anisotropic effect from an aromatic substituent of a chiral alcohol. In combination with chemical shift differences from both 19F NMR and 1H NMR, the F-THENA method can successfully be used for determining the absolute configuration of chiral secondary aromatic alcohols with a self-validating system.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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