Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor?

Chemical Communications Pub Date: 2006-09-29 DOI: 10.1039/B612154C

Abstract

Synthesis of a PUGNAc–imidazole hybrid and its characterization as an inhibitor of human O-GlcNAcase through enzyme kinetics and X-ray structural analysis.

Graphical abstract: Inhibition of O-GlcNAcase by a gluco-configured nagstatin and a PUGNAc–imidazole hybrid inhibitor
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