Hindered Br?nsted bases as Lewis base catalysts

Organic & Biomolecular Chemistry Pub Date: 2009-07-24 DOI: 10.1039/B908899G

Abstract

KHMDS and KOtBu are well established as strong, hindered, non-nucleophilic Br?nsted bases. However, in the present work these bases are applied as highly active Lewis base catalysts for the formal [2+2] cycloaddition of ketenes with aldehydes and imines.

Graphical abstract: Hindered Br?nsted bases as Lewis base catalysts
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