Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids?

Chemical Communications Pub Date: 2007-02-22 DOI: 10.1039/B618923G

Abstract

The magnesiation of halogenated aromatic and heteroaromatic carboxylic acids is accomplished by their treatment with MeMgCl in the presence of LiCl and subsequent reaction with i-PrMgCl·LiCl; the resulting double-magnesiated species react with a variety of electrophiles in up to 97% yield.

Graphical abstract: Halogen–magnesium exchange on unprotected aromatic and heteroaromatic carboxylic acids
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