Formal reductive addition of acetonitrile to aldehydes and ketones??
Organic & Biomolecular Chemistry Pub Date: 2018-09-28 DOI: 10.1039/C8OB01992D
Abstract
An efficient and highly productive rhodium-catalyzed method for the synthesis of nitriles employing aldehydes or ketones, methyl cyanoacetate, water and carbon monoxide as starting materials has been developed. Simple rhodium chloride without any ligands can be used. The fine tuning of the substrate can lead to the activity higher than 5000 TON.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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