Fluorinated enol ethers: their synthesis and reactivity

Organic & Biomolecular Chemistry Pub Date: 2015-05-28 DOI: 10.1039/C5OB00855G

Abstract

Thanks to the beneficial effect of fluorine substitution on the pharmacokinetic properties of molecules, an ever increasing number of marketed drugs incorporate a fluorine atom into their structure. As a consequence, the synthesis of fluorinated molecules has become a very active research field. Among the numerous approaches, fluorinated enol ethers are valuable building blocks that allow the introduction of a fluoro- or difluoromethyl group through a wide variety of reactions. The present review lists different methods for their preparation and sums up their numerous synthetic applications.

Graphical abstract: Fluorinated enol ethers: their synthesis and reactivity
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