Fluoride-catalyzed nucleophilic addition of PhSCF2SiMe3 to anhydrides: synthesis of γ-difluoromethylated γ-lactams?
Organic & Biomolecular Chemistry Pub Date: 2013-01-09 DOI: 10.1039/C3OB27193E
Abstract
PhSCF2SiMe3 (1) underwent fluoride-catalyzed nucleophilic addition to the carbonyl group of anhydrides to provide the corresponding γ-difluoro(phenylsulfanyl)methyl γ-lactols, which were employed for the synthesis of γ-difluoromethylated γ-lactams.
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Journal Name：Organic & Biomolecular Chemistry
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CAS no.: 89640-58-4
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