I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines?
Organic Chemistry Frontiers Pub Date: 2018-03-27 DOI: 10.1039/C8QO00063H
Abstract
An efficient and green protocol for the synthesis of acylated imidazo[1,2-a]pyridines and indolizines via intramolecular dehydrogenative aminooxygenation of alkynes has been developed. The reaction proceeds smoothly utilizing I2 as a catalyst and TBHP as an oxidant with a broad substrate scope. Mechanism studies reveal that the reaction maybe experiences a hydration followed by an oxidative cycloamination process.
![Graphical abstract: I2-Catalyzed intramolecular dehydrogenative aminooxygenation of alkynes to acylated imidazo[1,2-a]pyridines and indolizines](http://scimg.chem960.com/usr/1/C8QO00063H.jpg)
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Journal Name：Organic Chemistry Frontiers
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CAS no.: 89640-58-4
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